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WATER is a peer-reviewed journal that carries original papers, reviews, and tutorials from diverse disciplines on advances made within water-oriented research.
The article can be downloaded here.
Although there is considerable clinical research, homeopathy remains the subject of a heated debate. The special issue of the journal 'Homeopathy' makes an important contribution to this debate, by reviewing laboratory experiments with high dilutions. It includes reviews and new findings in biosystems, ranging from whole animal behavioral, intoxication and inflammation models through diseased and healthy plant models, to test tube experiments using isolated cells, cell cultures or enzymes.
Featured articles include one on the basophil degranulation test, a test tube model of allergy, developed by Jean Sainte Laudy. These results have now been confirmed in multi-centre and independent experiments. Other articles include systematic reviews of healthy and diseased plant models and experimental work on the effect of homeopathic arsenic on wheat seedlings. There are reviews of mouse and rat models of homeopathic responses and a review, including original results of animal models of homeopathic treatment of anxiety-like behaviours.
Other articles focus on the basic concept of homeopathy like cures like: in a series of cell-culture experiments Fred Wiegants team at the University of Utrecht demonstrated the importance of similarity. Christian Endler and his multinational team conclude that seven different biological models of high dilution response with positive results have been reproduced in multi-centre and/or independent experiments.
Editor-in-Chief Dr Peter Fisher commented: Throughout its 200 year history claims that homeopathy has real (as opposed to placebo) effects have been hotly contested. Our special issue brings together a wide range of scientific work in biological systems, where there can be no placebo effect, showing that there are now several biological experiments which yield consistently positive results with homeopathic dilutions.
Biological models of homeopathy Part 1
Homeopathy, Volume 98, Issue 4, Pages 183-302 (October 2009)
Biological models of homeopathy Part 2
Homeopathy, Volume 99, Issue 1, Pages 1-56 (January 2010)
See full contents and abstracts here.
A prospective multi-centre observational study describes the details and effects of an individualized homeopathic treatment in patients with chronic low back pain in usual care. The results come from a sub-group analysis of patients suffering from low back pain that were part of a large prospective multi-centre observational study population carried out over an 8-year period. Consecutive patients beginning homeopathic treatment in primary care practices were evaluated over 2 years by using standardized questionnaires.
Diagnoses (ICD-9) and symptoms with severity, health-related quality of life (QoL), medical history, consultations, homeopathic and conventional treatments, and other health service use were recorded. The study included 129 adults, treated by 48 physicians. Nearly all the patients (91.3%) had been pretreated. The severity of the diagnoses and complaints showed marked and sustained improvements with large effect sizes (Cohen's d from 1.67 to 2.55) and quality of life improved accordingly. The use of conventional treatment and health services decreased markedly: the number of patients using low back pain-related drugs was half of the baseline.
The authors conclude that individualized homeopathic treatment represents an effective treatment for low back pain. It improves health-related quality of life and reduces the use of other healthcare services.
Witt CM, Lüdtke R, Baur R, Willich SN (2009) Homeopathic treatment of patients with chronic low back pain: A prospective observational study with 2 years' follow-up. Clinical Journal of Pain, 25:334-339.
[abstract at PubMed]
A recently published study shows that patients with chronic sinusitis benefit from homeopathic treatment. The results come from a sub-group analysis of patients suffering sinusitis that were part of a large prospective multi-centre observational study population carried out over an 8-year period.
The study included 134 adults, treated by 62 physicians. Patients had suffered from chronic sinusitis for 10.7 +/- 9.8 years. Almost all patients (97.0%) had previously been treated with conventional medicine. They were followed up for 2 years, and complaint severity, health-related quality of life (QoL), and medication use were regularly recorded. For sinusitis, effect size of complaint severity was 1.58 (95% CI 1.77; 1.40), 2.15 (2.38; 1.92), and 2.43 (2.68; 2.18) at 3, 12, and 24 months respectively. Quality of life improved accordingly. The effects were still present after 8 years.
This observational study showed relevant improvements that persisted for 8 years in patients seeking homeopathic treatment because of sinusitis.
Witt CM, Ludtke R, Willich SN (2009). Homeopathic treatment of patients with chronic sinusitis: A prospective observational study with 8 years follow-up. BMC Ear Nose Throat Disorders, 9(1):7.
[it can be downloaded here]
20-MHz R1 and R2 water proton NMR relaxation rates were measured in ultrahigh dilutions (range 5.43·10^-8 - 5.43·10^-48) of histamine in water (Hist-W) and in saline (Hist-Sal), prepared by iterative centesimal dilutions under vigorous agitation in controlled atmospheric conditions. Water and saline were similarly and simultaneously treated, as controls. The samples were immediately sealed in the NMR tubes after preparation, and then code-labelled. Six independent series of preparations were performed, representing about 7000 blind measurements. R2 exhibited a very broad scatter of values in both native histamine dilutions and solvents. No variation in R1 and R2 was observed in the solvents submitted to the iterative dilution/agitation process. By contrast, histamine dilutions exhibited slightly higher R1 values than solvents at low dilution, followed by a slow progressive return to the values of the solvents at high dilution.
Unexpectedly, histamine dilutions remained distinguishable from solvents up to ultrahigh levels of dilution (beyond 10^-20 in Hist-Sal). A significant increase in R2 with increased R2/R1 was observed in Hist-W. R1 and R2 were linearly correlated in solvents, but uncorrelated in histamine dilutions. After a 10-min heating/cooling cycle of the samples in their sealed NMR tubes (preventing any modification of the chemical composition and gas content), all of the relaxation variations observed as a function of dilution vanished, the R2/R1 ratio and the scatter of the R2 values dropped in all solutions and solvents, and the correlation between R1 and R2 reappeared in the Hist-W samples.
All these results pointed to a more organized state of water in the unheated samples, more pronounced in histamine solutions than in solvents, dependent on the level of dilution. It was suggested that stable supramolecular structures, involving nanobubbles of atmospheric gases and highly ordered water around them, were generated during the vigorous mechanical agitation step of the preparation, and destroyed after heating. Histamine molecules might act as nucleation centres, amplifying the phenomenon which was thus detected at high dilution levels.
Demangeat J-L (2009). NMR water proton relaxation in unheated and heated ultrahigh aqueous dilutions of histamine: Evidence for an air-dependent supramolecular organization of water. Journal of Molecular Liquids, 144:32-39
[to be downloaded here]